Product detailed description

Why buy

^{PurovitalisTM} liposomal NMN capsules are a quick and easy way to get your daily dose of NMN on the go or for when you prefer capsules over powder.

Each vial contains 125 mg of NMN in one capsule, the recommended daily dose is 2 capsules. ^{PurovitalisTM} NMN capsules are made from high quality raw materials, 99.7% pure nicotinamide mononucleotide originating from Holland. Liposomes, on the other hand, come from Germany.

With ^{PurovitalisTM} NMN coming from Europe, they are the first company not to turn to China. In doing so, they reduce their carbon footprint without compromising the high standards of cleanliness they have set for themselves.

• The purity results can be found in the certificates of laboratory tests carried out in Germany by a third party and can be downloaded from the FILES tab.
• In the VIDEOS tab, check out recordings from TEDTalk, GoogleTalk, Time magazine and Dr David Sinclair's channel on how - very simply put - to slow down the biological clock with NAD+ boosting supplements.

NMN vs Spermidine

• Spermidine and NMN are the most popular dietary supplements available for longevity.
• Both increase the span of health, activate autophagy, protect cognitive function, strengthen the immune system and improve cardiovascular function.
• Spermidine improves multiple aging pathways (six out of nine) and appears to be better for beauty (skin, hair, nails) than NMN.
• In contrast, NMN, in turn, seems to be better able to stave off cognitive decline and restore youthful energy levels.
• A smart supplementation program includes both NMN and spermidine.

Dosage

The recommended daily dose is 2 capsules, i.e. 250 mg. Take preferably in the morning at breakfast and at lunch to follow your daily rhythm.

To get the same amount of NMN from food, you would have to eat 69 kg of avocado, 100 kg of broccoli or 416 kg of raw beef in a sitting.

• 30 capsules - 15 doses
• 60 capsules - 30 doses

Ingredients

Longevir™ NMN (β-nicotinamide mononucleotide), maltodextrin (bulking agent), lecithin (sunflower; emulsifier), HPMC (vegan; capsule).

Storage

• The manufacturer recommends not to expose the product to direct radiation or heat source, but to keep it cool and dark.
• Beware of humid environments.
• The packaging is dark glass, which protects the contents from light.

Attention

• It is a dietary supplement.
• Do not exceed the recommended daily dosage.
• Keep out of reach of children.
• The product is not intended as a substitute for a varied diet and is not intended to diagnose, treat, cure, or prevent any disease.
• The minimum expiry date is marked on the packaging.

Why the liposomal form of NMN

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme that is present in all human cells and plays an important role in, for example, the regulation of signaling pathways*, DNA repair, metabolism, cellular processes and aging.

Nicotinamide mononucleotide (NMN) is the precursor to NAD+ coenzyme in our body, which means that when you supply your body with NMN, your cells will convert it into NAD+, which will be able to work on the cellular processes mentioned above.

The use of dietary supplements with NMN is associated with the problem that the stomach breaks down the components of the supplement and reduces its stability and bioavailability. As a result, a large part of the active ingredients of the capsule is lost due to instability in the acidic environment in the stomach. Therefore, some hard core users take NMN intravenously under medical supervision.

In the case of ^{PurovitalisTM} NMN , this absorption problem is largely avoided thanks to the liposomal technology used.

Solution

The NMN supplement brand ^{PurovitalisTM} has strengthened the most well-known oral dietary supplement delivery system. Capsules with liposomal NMN have the following advantages:

HIGHER BIOAVAILABILITY

Many studies have shown that liposomal dietary supplements dissolve better than traditional ones.

PROTECTION

Liposomal NMN protects the active molecules from degradation by acid in the stomach. It provides your body with the highest amount of NMN in one capsule.

INCREASED ABSORPTION

Liposomes significantly improve product delivery by binding to the cells and releasing the active ingredients inside.

HIGHER CELLULAR ABSORPTION

Each batch of NMN is tested for purity and heavy metals by a third party laboratory to ensure purity greater than 99%.

Why take NMN as a dietary supplement

In June 2018, the World Health Organization (WHO) released the 11th edition of the International Classification of Diseases and included ageing for the first time. The classification of ageing as a disease opens the way for new research into new therapies to delay or reverse age-related diseases such as cancer, cardiovascular and metabolic diseases and neurodegeneration.

Nutrient sensing systems are under intense scrutiny, including mTOR (mammalian target of rapamycin) for regulating protein synthesis and cell growth, AMPK (activated protein kinase) for sensing low energy states, and sirtuins, a family of seven proteins critical for DNA expression and aging that can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.

Across the realm of life, increasing intracellular NAD+ levels induces changes that improve survival, including increased energy production and regulation of cellular repair. In fact, the slow, inevitable aging process is described as "a cascade of resistance breakdown triggered by a decline in systemic NAD+ biosynthesis and the resulting functional defects in susceptible organs and tissues."

Aging is characterized by epigenetic changes, genomic instability, altered ability to sense nutrients, telomere loss, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.

In middle age, the NAD+ level drops to half of what it was in youth. Numerous studies have shown that increasing NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and increases lifespan. NAD+ levels can be increased by activating enzymes that stimulate NAD+ synthesis, inhibiting an enzyme (CD38) that degrades NAD+, and supplementing NAD precursors, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).

A conceptual framework called NAD World, formulated over the past decade by developmental biologist Shin-ichiro Imai, MD, PhD, of the Washington University School of Medicine, envisions NMN as a critical, systemic signaling molecule that maintains the biological robustness of the NAD+-supporting communication network.

Tests on mice have clearly shown that NMN is clearly the mouse fountain of youth. But what about the people? Shin-ichiro Imai said that NMN can improve the metabolism of an adult human and bring it closer to that of a person ten or twenty years younger. His team is now studying NMN in humans.

David Sinclair, a well-known anti-aging researcher from Harvard University whose research on resveratrol, NAD+ and sirtuins is world-renowned, also conducts studies on humans. He himself takes NMN; according to his words, his lipid profile has improved significantly, he feels more energetic and his blood indicators are close to those of a 31-year-old man at the age of almost 60.

An interesting question is the delivery system of oral NMN: the EVs that transport the molecule through the plasma in the body are liposomes. The liposomal version of NMN may well mimic the body's own transport system, improving uptake and delivery as science advances in understanding the holy grail of reversing aging.

Read the full abstract of the above translated text and sources here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/#ref10